Water Fast Coaching and Nutritional Therapy

Dr. Tallis Barker | Extended Water Fasting Specialist | Registered Nutritional Therapist | Associate Naturopath

Autophagy, ketosis, detoxification: how water fasting works and why it benefits you

ARTICLE SECTIONS:

  • Why water fasting elicits powerful detox
    • (1) Autophagy and a break from digestion
    • (2) Fasting ketosis and fat-soluble toxins
  • Fasting ketosis vs. dietary ketosis
  • The time to fast and cleanse is now!
  • My Story

Why water fasting elicits powerful detox

There are countless diets, techniques and fads designed to help you detox. Many of these can certainly help, but if you’re really serious about cleansing, it’s also important to take an entirely different approach: through the practice of water fasting (or, alternatively, dry fasting).

Why? Because by sustaining a period of zero caloric intake, you can shift the body into a fundamentally different metabolic state. A number of physiological changes take place during fasting, and these can be thought of as occurring in two broad stages.

(1) Autophagy and a break from digestion

The first level of cleansing begins after your body has finished digesting its last meal. In this respect, what you eat impacts considerably. While most fruit and vegetables require only a few hours to digest, meals containing more fat and protein generally take significantly longer.

Digestion itself also consumes energy, in order to physically move food through the GI tract (peristalsis) as well as generate the enzymes required to break food down into its constituent nutrients. The heavier the diet, the more energy required to complete this process. In particular, the digestion of protein requires a lot of energy, demanding 20-30% of the calories contained in the given meal.[1]

When you stop eating, however, digestive activity naturally decreases, and the energy normally required for digestion can be directed elsewhere. Along with this, the body’s metabolism begins to shift towards using stored energy, given that the body is no longer actively processing a continual stream of food.

Taking a break from digestion also triggers autophagy: the process of degrading and eliminating cellular waste. If ‘detox’ can be defined as ‘the process of removing poisons or toxins from the body’,[2] then the autophagy triggered by fasting clearly constitutes a crucial step in this larger process of detoxification. Studies have shown that this upregulation of autophagy begins within the first 16-24 hours of fasting,[3] and can lead over the long term to lower LDL cholesterol levels and reduced inflammation markers such as CRP (C-Reactive Protein).[4] [5]

By definition, juice fasts and other cleanses which involve eating cannot achieve this to the same extent. Not only do they contain calories which reduce the need to depend on stored energy, but they also activate digestion, stimulating enzymes and peristalsis. Even simple juice triggers peristalsis. I have observed this among numerous clients when they break a water fast with juice: the end result often being a bowel movement within an hour or two.

(2) Fasting ketosis and fat-soluble toxins

The second, and in many ways deeper, metabolic shift begins once your body moves towards the fat-burning metabolism called ketosis. Described in greater detail in the articles about one-day water fasts and three-day water fasts, this process generally takes place after glycogen stores become depleted. This threshold is typically reached 24-36 hours after the onset of fasting. My clients who measure their blood or breath ketones regularly confirm this, also noting that ketone levels tend to rise through the first 5 days of fasting, after which they more or less plateau out.

Ketosis is important because it represents a fundamental change in the fuel your body is using. Rather than relying primarily on recently consumed food and stored glycogen, the body increasingly draws on stored fat. This is also the metabolic environment in which a number of fasting-related cellular processes become more active, including pathways associated with autophagy and cellular recycling, as noted in the section above.

One reason that fasting ketosis is so important for cleansing is that fat-soluble (lipophilic) toxins such as PCBs are normally sequestered and stored in adipose tissue (fat cells).[6] This keeps the given toxins out of the blood and body tissues, where they would otherwise cause damage. Over the long term, however, continued exposure means that the intracellular levels of such toxins can only rise.

The study cited above (Jandacek et al) demonstrated that rapid weight loss – such as that which would occur through fasting ketosis on a water fast – releases these toxins from adipose tissue into the blood. From here, the liver plays a crucial role in detoxification. Technically, this takes place especially through Phase I detoxification pathways in the liver, using enzymes such as cytochrome P450 (CYP)[7] to convert fat-soluble toxins (including PCBs) into water-soluble molecules, for subsequent elimination from the body.

In short, by drawing on fat cells for energy, fasting ketosis facilitates the release of fat-soluble toxins (such as PCBs) into the blood, for processing and elimination by the liver.

Some people following ketogenic or very-low-carbohydrate diets make the argument that ketosis itself provides the same cleansing benefits as fasting. There is certainly a metabolic overlap: both fasting ketosis and dietary ketosis increase fat utilisation and produce ketones. During a ketogenic diet, however, you are still eating, digesting and providing the body with an ongoing supply of nutrients and energy. (I explore this issue further in my video: Fasting Ketosis vs. Keto Diets: Why They Are Not the Same.)

As the study cited above also notes: it is specifically the element of rapid weight loss which triggers the release of intracellular fat-soluble toxins. This does not happen with dietary ketosis, which under normal circumstances assumes a relatively stable weight – in contrast to fasting ketosis.

So while dietary ketosis and fasting ketosis share important features, I would certainly not regard them as interchangeable. In fact, I repeatedly observe that clients who have followed long-term ketogenic / low-cqrb diets prior to their fasts tend to take longer to present with detox symptoms such as headaches or nausea during their fasts, as compared to clients who have followed lower-fat diets beforehand (typically 3-5 days as opposed to 2-3 days). This isn’t to imply that headaches and nausea are necessary side effects of every fast, but when they do present, the timing suggests to me that the pre-fasting diet itself must play a role in how quickly the body is able to make the metabolic shift into deep ‘cleansing mode’. I personally suspect that, given the liver’s leading role in emulsifying and digesting dietary fat, ketogenic diets effectively tie down a lot of the liver’s overall metabolic energy in a digestive role, which would likely put the liver at a disadvantage at the beginning of a fast.

This may have longer-term implications as well. Although it is impossible to establish a direct causal relationship, one widely cited observational study published in The Lancet Public Health (2018) found an association between very low carbohydrate intake and increased mortality, noting a possible decrease in lifespan of up to 4 years.[8] (The same study also noted a similar excess mortality to those following a very high carbohydrate intake.)

ONLINE COURSE

Complete a 3-day water fast

This video + pdf bundle provides you with all you need to know in order to safely, successfully and smoothly carry out your first 3-day water fast. If you already have a little experience, there are plenty of additional tips to help you go deeper into water fasting.

The time to fast and cleanse is now!

Unless you happen to live far from human civilisation, the air you breathe is likely to contain pollutants and carcinogens. Unless you drink straight from a mountain spring, the water you drink almost certainly contains added chlorine, along with the residue of microplastics, industrial waste products and hormones from the contraceptive pill – none of which cannot be fully filtered out by municipal water treatment plants. Unless you eat fully organic, your food was probably grown with the use of pesticides, fungicides and fertilisers. If you eat meat and dairy products, many farmers also treat their animals with antibiotics and artificial growth hormone. If you’ve recently been taking pharma drugs, your body may also contain metabolites from medication.[9]

The bottom line is that, like it or not, we face near constant exposure to chemicals and compounds which do not belong in our body.

I hope this is a wake-up call.

For me, the answer is fasting. I see the results with my clients. And as a practitioner I also experience it myself first-hand..

When I first tried out my very first water fast, I was shocked by what came out of my body. My breath stank. My sweat stank. My urine stank. My tongue turned a pasty white and began to literally froth, producing a bitter, metallic taste in my mouth lasting for days. I didn’t know exactly what physiological processes were taking place in my body, but I didn’t have to. It was utterly foul. And because it was so foul, it also felt good to eliminate it all from my body.

From that point on, I began to honour my body with regular fasting. And over the first couple of years of practice, I went from being the first person in the family to catch colds to being the last. As much as fasting was always a challenge – and even after all these years it’s still a challenge! – it also felt rewarding. It felt like I was getting closer to being able to listen to my body. And when deep in a fast, I began to find increased mental clarity and peace of mind.

Despite knowing the benefits, however, it’s all too easy to sit on the fence, knowing and feeling that you should fast, and yet not quite reaching the point of actual commitment. It might be anxiety about hunger and detox symptoms. It might be your work schedule. Who knows. We all have our reasons, and it’s easy to find an excuse. If you need help in making that final step towards a water fast, I’m here to support you as a water fasting coach.


[1] https://www.healthline.com/nutrition/negative-calorie-foods#fact-vs-fiction

[2] https://www.webmd.com/vitamins/ai/ingredientmono-1179/detoxification

[3] Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135. doi: 10.1038/nrm.2017.95. Epub 2017 Oct 4. PMID: 28974774; PMCID: PMC5780224

[4] Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6216-20. doi: 10.1073/pnas.1035720100. Epub 2003 Apr 30. PMID: 12724520; PMCID: PMC156352

[5] Shimokawa I, Higami Y, Utsuyama M, Tuchiya T, Komatsu T, Chiba T, Yamaza H. Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. Am J Pathol. 2002 Jun;160(6):2259-65. doi: 10.1016/S0002-9440(10)61173-X. PMID: 12057928; PMCID: PMC1850833

[6] Jandacek R, Liu M, Tso P. Interactions of Body Weight Loss with Lipophilic Toxin Storage: Commentary. J Nutr. 2024 Mar;154(3):801-803. doi: 10.1016/j.tjnut.2024.01.018. Epub 2024 Jan 18. PMID: 38244860; PMCID: PMC10942849

[7] Roach, C.M., Koester, N.R., Li, X. et al. 3,3′-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation. Arch Toxicol 100, 943–957 (2026). https://doi.org/10.1007/s00204-025-04241-7

[8] Seidelmann S, Claggett B, Cheng S et al. Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. The Lancet Public Health, 2018; 3, e419-e428

[9] https://www.thefreedomcenter.com/how-long-does-it-take-for-a-drug-to-be-cleared-from-the-body/

The webshop offers downloadable fasting plans and guides to help make your water fast a success.

If you enjoyed this article, please share on social media, using one of the buttons below:

50 responses to “Autophagy, ketosis, detoxification: how water fasting works and why it benefits you”

  1. Hello Tallis,
    I’ve scoured the internet and now your website. Frankly, I’m surprised your site hasn’t come up at the top of my search. I would’ve saved plenty of time.
    2.5 years postcovid with now constant central joint pain that seems to be affecting peripheral joints, intensifying headache, and fight and flight feeling every time I put anything in my mouth, I am into 65th hour of my second long term fast in 8 years. This time it’s different.
    There is lots of dizzyness and increased fatigue already! Is this expected to go away at some point, or am I expected to suffer for the entire fast?

    1. Dr. Tallis Barker, D.Phil., Nat.Dip. Avatar
      Dr. Tallis Barker, D.Phil., Nat.Dip.

      Hi Tamy,
      Thanks for sharing, and I’m glad you’re finding the website useful. To answer your question: dizziness and fatigue have multiple causes (which is maybe why you say it feels different this time?), and this makes it very difficult to say anything beyond this without working together more closely. It does sound like you have a lot going on in your body, and, from my perspective as a water fasting coach, complex cases involving Long Covid are often the most difficult to guide. So my advice to you is to be very careful in ascertaining the length of your fast as well as your post-fasting diet.
      Hope this helps,
      Tallis

  2. Hello Tallis,
    Thank you for all the incredible information and advice you’re giving here!
    I have a question with regards to my first long-term fasting last year.
    I barely reached day 11 and I wanted to do more for deep healing of the muddle ear myoclonus I have, but I had to stop the fat since I was experiencing a very strong thirst, though I would usually drink 3 or more litres of water.
    Please can you let me know how to overcome the thirst (I tried different waters) and explain what have possibly caused it? The more water I would drink, the tthirstier I would be and my mouth would feel extremely dry.
    Thank you very much for your time to look into this matter. 😀
    I’m currently on my 4th day fast and wish to continue for a long as I can.
    Best Regards!

    1. Tallis Barker, D.Phil., Nat.Dip. Avatar
      Tallis Barker, D.Phil., Nat.Dip.

      Hi Li,
      You’re welcome, and I’m glad you’ve found the website useful. Understanding thirst and understanding what thirst really means is a subtle issue which often comes up with my clients in daily coaching sessions. I would always say that fasting is a wonderful opportunity to listen to your body and increase your connection with what your body is trying to say – and this is a good example of that. If drinking more water actually makes your mouth drier, what is that saying?…

      There’s no need to drink to a prescribed quantity – which is merely a random volume of fluid determined by a mental decision which may or may not have anything to do with the true needs of your body. Some people need to drink 4 litres a day, other people need to drink 1 litre a day, and everybody’s true thirst will fluctuate from day to day. Although many people never think about it, learning to understand true thirst is as important as learning to understand true hunger (which equally confuses most people – with emotional cravings and true physical needs becoming completely intertwined and confused over a lifetime).

      Your plan to fast for 14 days is a good initial plan, but you’ll need to see how healing develops through the fast to decide what is best.

      Hope this helps,
      Tallis

  3. Does loose leaf herbal tea sugar free impact a water fast?

    1. Tallis Barker, D.Phil. Avatar
      Tallis Barker, D.Phil.

      Hi Julie,
      Thanks for writing. Everything is going to have some kind of impact on a water-only fast. You certainly wouldn’t want to take anything beyond water on a primarily spiritual fast, since the whole point is to remove external stimulation. If your primary aim is physical healing, non-caffeinated herbal teas can certainly play a role. When working with clients I often suggest a particular herb in order to deal with certain detox symptoms, so their medicinal value is worth keeping in mind.
      All the best,
      Tallis

  4. Hi! Great article! I’ve been experimenting with various water fasts between 1-3 days, but tend to struggle with toxicity symptoms at the 72-hour mark and have to stop. One thing that continues to confuse me regarding long-term water fasts (20-40 days) is, if certain nutrients are essential for Phase 1 & 2 liver detoxification to take place (e.g. B vitamins and amino acids) and some of these can only be obtained through the diet, how does detoxification continue when consuming zero nutrients on a prolonged water fast? I can find lots of information on water fasting and plenty on detoxification, but can’t find anything on detoxification during fasting! If you have any thoughts/info on this, I’d be most interested 🙂 Thanks!!

    1. Tallis Barker, D.Phil. Avatar
      Tallis Barker, D.Phil.

      Hi Donna,
      Thanks for your question: it’s one which makes an awful lot of sense! First of all, detox does clearly continue on 20-40 day fasts – in fact it only goes deeper the longer you go! In terms of Phase 1+2 liver detox, the nutrients/enzymes involved can largely be recycled by the body, as they facilitate the biochemical reactions taking place. So it’s not like you’re just dumping them out of the body. Also, the liver retains additional nutritive stores for everything it needs to maintain function, so it’s usually well prepared for something even as extreme as a 40-day fast.
      Hope this helps,
      Tallis

  5. Greetings, Tallis! I recently learned about the body making stem cells during a 72+ hour fast. I did a 42 hour fast a couple of weeks ago, and am currently at hour 54 this time going for 92. My question is, have you had any experience with muscle regeneration with the stem cell production? If-so, how long should I push it for & how often (depending on cycle days)? I’m trying to avoid surgery on my torn rotator cuff. PRP injections did nothing. Praying this extended water fasting might do the trick as stem cell injection$ are wild ($$$$). Thank you for your time!

    1. Tallis Barker, D.Phil. Avatar
      Tallis Barker, D.Phil.

      Hi Dre,
      Thanks for writing. Medical science loves promoting exciting terminology – such as ‘stem cell production’. Not surprisingly, stem cell injections are now big business, whether in cases like yours or (especially nowadays) in order to heal from Long Covid. I’ve had numerous clients come to me because they’ve really not seen much improvement through expensive injections.

      The fact is that stem cell production is only a minute slice of the entire ‘healing pie’. If you’re trying to avoid surgery on your rotator cuff, then there’s certainly a chance that fasting will help, but a lot is going to depend on the severity of your injury, the length of your fast and the strength of your immune system. Unfortunately, I can guarantee you that – although 92 hours is a good start – it certainly isn’t long enough to allow the depth of healing required to resolve your issue. 10 days is likely to be a bare minimum. Without knowing more of your details, I suspect you’ll need to fast considerably longer than that too.

      Hope this helps,
      Tallis

  6. Michael Massetti Avatar
    Michael Massetti

    Does consumption of coffee or beverages with 0 calories (Stevia) impact the fast at all? Thank you.

    1. Tallis Barker, D.Phil. Avatar
      Tallis Barker, D.Phil.

      Hi Michael,

      Thanks for writing. The short answer is YES!!! Coffee is both acidic and contains caffeine. Over an extended fast, the acids can cause both acid reflux and an intensification of other detox symptoms – given that all products of detox are themselves acidic to begin with. Caffeine accelerates metabolic rate, when instead you should be slowing down in order to maximise healing. Certain well-known MDs do promote the use of coffee for fasting, but unfortunately it seems they don’t understand the difference between short-term and long-term fasts. Don’t get me wrong, I do love a cup of freshly ground coffee in everyday life, but I would NEVER fast with it.

      Stevia doesn’t contain calories, so to that extent it won’t interfere with ketosis, but the sweet taste is going to do nothing to help you overcome your addiction to sweets and sugars!

      Hope this helps,
      Tallis

  7. Hello Sir, I started a fast and wanted to fast for 10 days but I stopped at day 6 because my friends noticed I had jaundice in the eyes. I am wondering why this happened and should it be of concern? Is it OK to continue to fast?

    1. Tallis Barker, D.Phil. Avatar
      Tallis Barker, D.Phil.

      Hi Charles,
      Thanks for writing. When the liver becomes overloaded and is unable to process the blood to the fullest extent, jaundice in the eyes is a common consequence. I’m afraid that without discussing the details of your case in person, I can’t comment on whether it would be safe and suitable to continue. However, I would always urge people to err on the side of caution, especially if they don’t have personalised advice from a fasting expert. In that sense, you did the right thing to stop.
      All the best,
      Tallis

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Discover more from Water Fast Coaching and Nutritional Therapy

Subscribe now to keep reading and get access to the full archive.

Continue reading